The Utility of the Systemic Immune-Inflammation Index (SII) and the Systemic Immune-Response Index (SIRI) in predicting pregnancy-related cerebral venous sinus thrombosis: An experience from a tertiary center

Authors : Ezgi Başaran, Atakan Tanacan, Nihat Farisoğulları, Zahid Ağaoğlu, Hakkı Şerbetçi, Özgür Kara, Namık Özcan, Dilek Sahin
Pages : 255-261
Doi:10.38136/jgon.1578867
View : 20 | Download : 35
Publication Date : 2025-09-30
Article Type : Research Paper
Abstract :Aims: Our aim in this study was to investigate the difference of systemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) indices between pregnancy-related cerebral venous sinus thrombosis (CVST) patients and healthy pregnant and postpartum women and to evaluate the association between these indices and disease severity and prognosis in the CVST group. Materials and Methods: This retrospective study included 21 patients with CVST and 80 healthy pregnant and postpartum patients as the control group. We looked at whether there was a statistical difference in demographic and clinical characteristics and laboratory results between the groups. Then we compared the SII and SIRI values, whose prognostic value has been studied as new inflammatory indices in many subjects. Results: Neutrophil, monocyte, lymphocyte and platelet counts were similar between the groups. SII and SIRI were significantly higher in the CVST group (p:0.006, p:0.043; respectively). It was found that the SII and SIRI indices were higher in the group with severe disease and the poor prognosis, but the results were not statistically significant. Conclusion: These results showed us that the SII and SIRI indices can be used as a supporting factor for the diagnosis in patients with suspected CVST. Studies with more patients may help to demonstrate the impact of SII and SIRI indices on disease severity and prognosis.
Keywords : serebral venöz sinüs trombozu, gebelik, sistemik inflamatuar yanıt indeksi, sistemik immün inflamasyon indeksi, trombo-inflamatuar belirteçler

ORIGINAL ARTICLE URL