Effect of Prenatal Magnesium Sulphate on Hearing Function in Premature Newborns

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Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi
Cilt: 22 Sayı: 3
Effect of Prenatal Magnesium Sulphate on Hearing Function in Premature Newborns

Effect of Prenatal Magnesium Sulphate on Hearing Function in Premature Newborns

Authors : Dilara Sarıkaya Kurt, Yüksel Oğuz, Can Ozan Ulusoy, Ahmet Kurt, Aziz Kından, Recep Taha Ağaoğlu, Kadriye Yakut Yücel

Pages : 241-246

Doi:10.38136/jgon.1588776

View : 52 | Download : 60

Publication Date : 2025-09-30

Article Type : Research Paper

Abstract :Objective: The study aimed to evaluate the potential neuroprotective effects of antenatal magnesium sulfate (MgSO4) on sensorineural hearing and auditory nerve development in premature newborns. Methods: This retrospective study included premature newborns (<37 weeks) born between November 1, 2022, and December 31, 2023, at Etlik City Hospital. Newborns were divided into two groups: those exposed to antenatal MgSO4 (study group, n=40) and those unexposed (control group, n=126). Antenatal MgSO4 was administered at 2 grams/hour for at least 8 hours after a 6-gram loading dose. Hearing screening was conducted using auditory brainstem response (ABR) tests within the first month after birth. Maternal and neonatal characteristics, including gestational age, birthweight, and Apgar scores, were analyzed. Statistical comparisons between groups were performed using appropriate tests, with a significance level of p<0.05. Results: The failure rate in hearing screening tests did not significantly differ between the MgSO4 group (10%) and the control group (6.3%) (p=0.437). However, the MgSO4 group had lower gestational age at birth (median: 30.0 vs. 34.0 weeks, p<0.001), lower birthweight (median: 1424 vs. 2325 grams, p<0.001), and higher rates of Apgar scores below 7 at both the 1st and 5th minutes. Placental abruption, retinopathy of prematurity, and bronchopulmonary dysplasia were associated with hearing abnormalities in the overall cohort. Conclusion: Antenatal MgSO4 administration did not demonstrate a significant protective effect against hearing impairment in premature newborns. Larger prospective studies are warranted to clarify MgSO4\\\'s role in auditory neuroprotection.
Keywords : Magnezyum Sülfat (MgSO4), Antenatal Nöroproteksiyon, Prematüre Yenidoğan, Sensorinöral İşitme Kaybı

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