Mean Platelet Volume A Potential Indicator for Preeclampsia

Authors : Kamuran Suman, Zafer Bütün, Musa Büyük

Pages : 297-299

Doi:10.38136/jgon.1616464

View : 24 | Download : 34

Publication Date : 2025-09-30

Article Type : Other Papers

Abstract :Objective: This study aims to determine the frequency of thrombocytopenia in infants born to mothers with pregnancy-induced hypertension characterized by high blood pressure and proteinuria, such as preeclampsia. Additionally, the thrombocytopenic infants\\\' platelet volumes (MPV) will be compared to those of infants born from normal pregnancies. The results of this study can provide insights into the health status of infants experiencing thrombocytopenia during the pregnancy process. Moreover, the relationship between thrombocytopenia and MPV will be examined, and understanding this relationship will help us better comprehend the impact of thrombocytopenia. Methods: This study aims to determine the differences in platelet counts and mean platelet volume (MPV) between newborns of preeclamptic mothers who develop thrombocytopenia and those who do not, as well as newborns from normal pregnancies. To attain this objective, a total of 60 infants with comparable gestational ages were segregated into three distinct groups. The first group comprised 20 infants born to mothers suffering from preeclampsia who exhibited thrombocytopenia (Group A), the second group included 20 infants born to mothers with preeclampsia but without thrombocytopenia (Group B), and the third group consisted of 20 infants born to mothers with uncomplicated pregnancies (Group C). Using hematological data obtained from medical records, the newborns\\\' birth weights, platelet counts, and MPVs were compared according to the first 72 hours of life. These analyses aimed to determine the impact of thrombocytopenia on newborns\\\' birth weights and platelet counts and to investigate the relationship between thrombocytopenia and MPV. Results: According to the findings of this study, it was observed that as the platelet count decreased in newborns of preeclamptic mothers with thrombocytopenia, mean platelet volume (MPV) values increased. In Group A infants, where platelet counts were the lowest, the highest MPV values were observed. However, statistical analysis revealed no significant correlation between MPV and platelet counts. Additionally, no significant difference was detected between the groups in terms of MPV values (p=0.053). Conclusion: The findings of this study suggest that as the likelihood of developing thrombocytopenia in preeclamptic mothers increases, the volumes of platelets can change, which can affect MPV values. However, the lack of correlation between MPV and platelet counts emphasizes that thrombocytopenia alone is not sufficient evidence and that platelet functions should also be considered. Therefore, these findings highlight the importance of monitoring both platelet counts and functions in the case of thrombocytopenia in infants born to preeclamptic mothers. An increase in platelet volume is considered an indicator of platelet destruction, while a decrease is considered an indicator of insufficient platelet production. The results of this study demonstrate that the etiology of thrombocytopenia observed in infants born to preeclamptic mothers cannot be explained solely by platelet volume. This suggests that factors other than platelet reduction or destruction may also contribute to the development of thrombocytopenia. Therefore, platelet volume alone cannot be used as an indicator, and other factors, including platelet production and destruction, must also be considered. In conclusion, further research is needed to investigate the causes of thrombocytopenia in infants born to preeclamptic mothers.
Keywords : Preeklampsi, orta trombosit hacmi, trombosit sayısı

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