Evaluation of Cardiac Autonomous Functions in Patients with Chronic Glomerulonephritis

Authors : Burcu Çakır, Gökay Taylan, İlhan Kurultak, Sedat Üstündağ

Pages : 71-79

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Publication Date : 2025-04-30

Article Type : Research Paper

Abstract :Aim: Our study aims to investigate the presence of autonomic dysfunction, which is one of the important causes of cardiovascular mortality, by evaluating heart rate variability and heart rate turbulence in patients with chronic glomerulonephritis Material and Methods: In this case-control study, 42 individuals with chronic glomerulonephritis classified as stage 1–3 chronic kidney disease and 102 age- and sex-matched healthy subjects were compared in terms of heart rate variability and heart rate turbulence. Subgroup analyses were performed by dividing the patient group into nephrotic and nephritic syndrome subgroups. p<0.05 was accepted as significant. Results: In the glomerulonephritis group, significant decreases were observed in heart rate variability parameters, indicating that cardiac autonomic functions changed in favor of sympathetic activation. When subgroup analysis was performed, it was observed that the decrease in the parameters representing parasympathetic activation of heart rate variability continued in the nephritic syndrome group. Conclusions: This study demonstrated that autonomic dysfunction characterized by parasympathetic suppression and sympathetic activation is present in patients with chronic glomerulonephritis, even in the early stages of chronic kidney disease.
Keywords : glomerulonephritis, cardiac autonomic function, heart rate variability, heart rate turbulence

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