INVESTIGATION OF TOXICOLOGICAL PROPERTIES OF SOME AZO DYES BY OECD QSAR METHOD

Authors : Yasemin KEŞKEK KARABULUT, Yelda YALÇIN GÜRKAN

Pages : 1-22

Doi:10.34186/klujes.1242876

View : 67 | Download : 42

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :In this study, the toxicological properties of some of the aromatic amine raw materials commonly used in textile dyes and the dyestuffs produced from these raw materials were examined with the OECD QSAR method and their toxicological effects on human health were investigated. In the literature review conducted with the relevant structures, it was seen that no study set was found in terms of toxicology, considering the comparison of raw materials and products. Studies have found that some aromatic amine raw materials and azo dyes produced from these raw materials are generally moderately irritating. While the related raw materials generally have eye irritant properties, the products do not have any irritating properties. It can be said that 12 aromatic amine raw materials and 13 azo dyes have skin sensitizing properties. The raw materials are 2,6-dibromo-4-nitro aniline, 6-methoxybenzothiazole-2-ylamine, 2-Bromo-4,6-dinotroaniline, and azo dyes, which are Disperse Brown 27-1, Disperse Brown 19 and Disperse Blue 291, are mutagenic.
Keywords : Toksisite, Aromatik Aminler, Azo Boyalar, OECD QSAR

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