The Effects of High Calcium and Vitamin D on the Fructose- Induced Lipogenesis Pathway in Rats

Authors : Semiha Özge Kara, Akın Yakan

Pages : 541-555

Doi:10.30607/kvj.1319111

View : 46 | Download : 58

Publication Date : 2023-12-31

Article Type : Research Paper

Abstract :In this study, the protective effects of high amounts of dietary calcium and vitamin D on fructose-induced lipogenesis were investigated at molecular and biochemical levels. Control group (Con, n=8), High fructose diet group (F, n=8), High fructose diet+75 mg CaCO3 and 26.4 IU vitamin D3 group (FCaD1, n=8), High fructose diet+150 mg CaCO3 and 52.8 IU vitamin D3 group (FCaD2, n=8) including experimental groups were fed for 28 days. The significant difference between the living weights was determined firstly as 278.64±5.61a; 268.94±2.80ab; 257.93±4.86b and 257.38±3.42b g in the Con, F, FCaD1, FCaD2 groups, respectively, at the end of the first week (P<0.05). This difference was seen to persist during the 3rd week of the trial. It was observed that this difference continued until the end of the 3rd week of the study. In the study, plasma Triglyceride (TG) amount was found to be in the form of 36.25±2.76b; 99.13±15.63a; 98.50±18.00a and 79.88±9.33ab mg.dl-1 in Con, F, FCaD1 and FCaD2 groups, respectively (P<0.05). The SCD-1 gene\'s liver expression levels were assessed as 11.83±2.08 (P<0.001); 5.31±1.40 (P<0.05) and 5.18±1.43 (P<0.05), respectively, compared to the Con group; SREBP-1c was determined as 2.11±0.37 (P<0.05); 3.41±1.20 (P<0.05) and 1.79±0.30 (P<0.05), respectively. In this study, it has been shown through the SREBP-1c and SCD-1 genes that calcium-vitamin D supplementation can have positive effects in a short time against lipogenesis induced by high fructose diet.
Keywords : Fruktoz, Kalsiyum, Karaciğer, Lipogenez, Vitamin D