Protective Effect of Chlorogenic Acid Against Testicular Damage Induced By Glyphosate Isopropilamine in Rats

Authors : Ruhi Türkmen, Yavuz Osman Birdane, Orkun Atik, Hasan Hüseyin Demirel, Türkan Türkmen, Özay Güleş

Pages : 334-340

Doi:10.30607/kvj.1520615

View : 80 | Download : 82

Publication Date : 2025-01-03

Article Type : Research Paper

Abstract :The aim of this subchronic toxicity study was to determine the prophylactic effect of chlorogenic acid (CGA) on the histopathologic-histologic changes and oxidative stress induced by Glyphosate isopropylamine (GLF-ISO) in testicular tissues. A sum of 42 male Wistar rats were divided into six equal groups, each containing 7 rats. For pretreatment, rats were given CGA at doses of 12.5, 25 and 50 mg/kg (po) and GLF-ISO at 787.85 mg/kg (po) for 7 weeks. GLF-ISO significantly increased malondialdehyde levels while decreasing SOD and CAT activities and GSH levels in testicular tissues. On the contrary, these parameters were improved in CGA-treated groups. Furthermore, CGA ameliorated the histopathological and histological changes in testicular tissues induced by GLF-ISO in a dose-dependent manner. The results indicate that testicular damage caused by GLF-ISO can potentially be prevented or managed by CGA.
Keywords : Glyphosate İzopropilamin, Klorojenik asit, Oksidatif stres, Testiküler hasar

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