Are the conventional risk factors still valid for acute myeloid leukemia patients?

Authors : Abdulkerim Yıldız, Senem Maral, Murat Albayrak, Çiğdem Pala, Pınar Cömert, Hacer Berna Afacan Öztürk, Osman Şahin

Pages : 5-11

Doi:10.18521/ktd.549666

View : 25 | Download : 9

Publication Date : 2020-03-02

Article Type : Research Paper

Abstract :Objective: The aim of this study was to investigate the survival data of patients with acute myeloid leukemia (AML) and to determine the risk factors that can be easily evaluated. Method: A retrospective analysis  was made of the AML patients admitted to our center between 2009-2018. Demographic data and disease data were analyzed and response rates, overall survival (OS) and progression-free survival (PFS) rates were calculated. Factors affecting survival were determined using Cox-regression analysis. Results: A total of 119 patients were included in the study during the 9-year study period. Of these, 21 patients had secondary AML and 11 had acute promyelocytic leukemia (APL). The mean follow-up period was 12.43 ± 15.63 months. OS of all patients was 9.20 months and PFS was 7.23 months. Age and leukocyte count at the time of diagnosis were found to have a significant impact on both OS and PFS (p <0.05). Conclusion: In addition to genetic and molecular features, which are expensive and not easily available, the age and leukocyte count of AML patients remain important as prognostic factors.
Keywords : leukemia, survival, age