Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients

Authors : Fatih KURT, Recep ERÖZ, Kenan KOCABAY

Pages : 59-68

Doi:10.18521/ktd.1162175

View : 30 | Download : 13

Publication Date : 2023-03-15

Article Type : Research Paper

Abstract :Objectives: This study was carried out to compare the expression levels of ASCinsert ignore into journalissuearticles values(Apoptosis Associated Speck Like Protein Containing a CARD);, TL-1ainsert ignore into journalissuearticles values(TNF Like Factor 1a); and CXCL 13insert ignore into journalissuearticles values(B Cell Chemoattractant Chemokine Ligand 13); genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Düzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF. Method: 36 patients insert ignore into journalissuearticles values(20 girls, 16 boys); and 12 healthy controls insert ignore into journalissuearticles values(7 girls, 5 boys); were included in the study. RNA was isolated from the peripheral blood of each individual and expression levels of ASC, TL-1a and CXCL 13 genes were determined. Routine biochemical parameters were also determined. Result: CXCL 13 and TL-1a gene expression levels were significantly increased in patients with FMF, the expression level of the ASC gene was found to be increased in FMF patients, but not significantly. Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.
Keywords : AAA, ASC, CXCL 13, TL 1a