Relationship of Vitamin B12 and Vitamin D with IL-4, IL-10, TNF Beta in Obese Patients

Authors : Gonca GÜLBAY, Yasemin KAYA

Pages : 99-104

Doi:10.18521/ktd.1211939

View : 20 | Download : 12

Publication Date : 2023-03-15

Article Type : Research Paper

Abstract :Objective: We aimed to investigate the relationship of vitamin B12 and vitamin D with IL-4, IL-10 and TNF-Beta in obese patients. Methods: Serum IL-4, IL-10 and TNF-Beta levels were measured using kits based on the enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA); principle. Results: The IL-10 level was found to be significantly lower in the low vitamin D group insert ignore into journalissuearticles values(p= 0.039);. When vitamin B12 normal, vitamin B12 low and control groups were compared, a statistical difference was found between the groups in terms of IL-10 insert ignore into journalissuearticles values(p=0.002);. As a result of post hoc analysis, the IL-10 level was found to be significantly lower in the vitamin B12 low group than in the vitamin B12 normal group insert ignore into journalissuearticles values(0.04);. At the same time, vitamin B12 was statistically higher in the normal group insert ignore into journalissuearticles values(obesity positive); than in the control group insert ignore into journalissuearticles values(non-obese vit B12 normal); insert ignore into journalissuearticles values(p=0.001);. A positive correlation was found between vitamin B12 and IL-10 insert ignore into journalissuearticles values(r= 0.203 p= 0.058);. Conclusion: It has been shown that low levels of vitamin D and vitamin B12 in obese patients cause low levels of IL-10. It was also found that obesity caused an increase in IL-10 levels. No relationship was found between IL-4 and TNF-Beta and vitamin D and vitamin B12. Longer follow-up and studies in larger case populations are needed to better understand the effects of vitamin B12 and vitamin D on IL-4, IL-10 and TNF-Beta levels in obese patients.
Keywords : IL 10, IL 4, TNF beta, Vitamin B12, Vitamin D, Obezite