Therapeutic Potential of Cepharanthine in Ovarian Ischemia-Reperfusion Injury: Insights from a Rat Ovarian Torsion-Detorsion Model

Authors : Burak Bircan, Ayhan Tanyeli, Ersen Eraslan, Fazile Nur Ekinci Akdemir, Şahin Yazici, Derya Güzel, Elif Polat, Mustafa Can Güler

Pages : 110-118

Doi:10.62425/jlasp.1673052

View : 84 | Download : 93

Publication Date : 2025-09-19

Article Type : Research Paper

Abstract :This study evaluated the potential protective effects of Cepharanthine (CEP) in mitigating ischemia-reperfusion (I/R) injury of an ovarian torsion/detorsion (T/D) rat model. Twenty-four female Sprague-Dawley rats were randomized into three experimental groups: sham, T/D, and CEP 10 mg/kg. The study examined ovarian tissue samples to measure oxidative stress biomarkers, such as malondialdehyde (MDA), myeloperoxidase (MPO), and superoxide dismutase (SOD), as well as proinflammatory mediators, specifically tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β). The T/D group exhibited significant oxidative stress, characterized by elevated MDA and MPO levels and low SOD activity, along with heightened inflammatory responses, as indicated by elevated TNF-α and IL-1β levels (p<0.05 vs. Sham). CEP administration mitigated these deleterious effects, significantly reducing oxidative stress and inflammatory cytokine levels while restoring SOD activity (p<0.05 vs. T/D). CEP effectively attenuates oxidative stress and inflammation in ovarian I/R injury, highlighting its therapeutic potential for ovarian torsion and related gynecological emergencies. Further studies are warranted to explore its clinical applicability.
Keywords : Cepharanthine, İskemi reperfüzyon, Over torsiyon detorsiyon, Oksidatif stres, İnflamasyon

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