Investigation of Oxidative/Antioxidant Effects of Turmeric (Curcuma longa L.) Supplementation on Heart Tissue in Adult Rats

Authors : Şevkinaz DOĞAN, Aslıhan CESUR TURGUT

Pages : 183-188

Doi:10.24998/maeusabed.1265094

View : 63 | Download : 58

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :n present study, the effects of curcumin supplementation on oxidative stress and antioxidant defense system in heart tissue in adult rats were investigated. Sixteen rats insert ignore into journalissuearticles values(8-weeks-old); were selected and divided into two groups. The first group is the experimental group and these rats insert ignore into journalissuearticles values(n=8); were gavaged with curcumin, dissolved in corn oil, at a dose of 300 mg/kg per day for 28 days. The second group is the control group, rats in this group were given curcumin and equal amount of corn oil to eliminate the porter effect. Euthanasia was performed and total antioxidant capacity insert ignore into journalissuearticles values(TAS);, total oxidant capacity insert ignore into journalissuearticles values(TOS);, malondialdehyde insert ignore into journalissuearticles values(MDA); and glutathione insert ignore into journalissuearticles values(GSH); levels were analyzed from heart tissues. Curcumin supplementation resulted in significantly increased GSH levelsinsert ignore into journalissuearticles values(P 0.05);. The total antioxidant capacity insert ignore into journalissuearticles values(TAS); and total oxidant capacity insert ignore into journalissuearticles values(TOS); ratios were found to be statistically significant. In the other group supplemented with curcumin, MDA levels tended to decrease compared to the control group, and there was no statistically significant difference between the two groups. Curcumin supplementation protects the heart tissue against oxidative damage and strengthens the antioxidant defense system in adult rats.
Keywords : Kurkumin, antioksidan, oksidatif stres, kalp