Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs

Authors : Özlem ÖZMEN, Ezgi OGUS

Pages : 106-110

Doi:10.24880/maeuvfd.481960

View : 24 | Download : 15

Publication Date : 2018-12-30

Article Type : Research Paper

Abstract :Transmissible venereal tumor insert ignore into journalissuearticles values(TVT); is a sexually transmitted, naturally occurring tumor of the canine family and often occurs in tropical and subtropical countries. The matrix metalloproteinases insert ignore into journalissuearticles values(MMPs); are endogenous proteases accountable for the degradation of extracellular matrix insert ignore into journalissuearticles values(ECM); components, such as collagen and other proteins including the basement membrane. MMPs play a vital role in the tumor metastasis and angiogenesis. Both MMP-2 and -7 strongly associated with the invasion and metastasis of different cancer types. This study aims to investigate the MMP-2 and -7 expression in naturally occurring TVT in 20 dogs using immunohistochemical methods. Immunohistochemically, we observed increased MMP-2 and -7 expressions in tumor cells. In addition, a positive correlation was determined between the tumor size and immunoexpressions of the markers indicating that both MMP-2 and -7 participate in the TVT pathogenesis .
Keywords : dog, pat