Evaluation of albendazole treatment on coagulation profile in sheep naturally infected with Dicrocoelium dentriticum

Authors : Hasan ERDOĞAN, Mehmet GÜLTEKİN, Kerem URAL, Yasin PARLATIR, Adnan AYAN, Songul ERDOĞAN, Serdar PAŞA

Pages : 8-13

Doi:10.24880/maeuvfd.523108

View : 20 | Download : 11

Publication Date : 2019-06-30

Article Type : Research Paper

Abstract :The aim of the present study was to evaluate the selected coagulation profile parameters in sheep naturally infected with  Dicrocoelium dentriticum  and effects of albendazole treatment .  For this reason, 34 merino sheep, aged between 1 and 3 years, naturally infected with  Dicrocoelium dentriticum were enrolled in the present study. Plasma and stool samples were withdrawn from each animal before and 10 days after treatment and egg per gram feces were evaluated with Mc Master technique. Prothrombin time activated partial thromboplastin time and fibrinogen levels were determined by semiautomated coagulometer by using commercial test kits before and 10 days after treatment. Noticeable clinical recovery was detected in all animals after albendazole treatment. There were significant differences on Prothrombin time and fibrinogen levels a p value of insert ignore into journalissuearticles values(p<0.001); between treatment intervals. In conclusion, this is the first study for selected coagulation parameters before and after albendazole treatment for ovine patients naturally infected with  Dicrocoelium dentriticum . It should be mentioned that the treatment resulted in lower prothrombin time and fibrinogen values, suggesting that dicrocoeliasis might alter coagulation profile and possibly induce an acute phase response. Furthermore, the clinical relevance in ovine medicine and related results possibly interacting to human medicine has to be determined by future studies.
Keywords : Activated partial thromboplastin, anthelmintic, fibrinogen, liver fluke, prothrombin