Investigation of antiproliferative effects of Hypericum perforatum oil on myeloma cells

Authors : Soner TUTUN, Muhammet Mükerrem KAYA, Melike Sultan USLUER, Hidayet TUTUN

Pages : 79-82

Doi:10.24880/maeuvfd.728975

View : 24 | Download : 15

Publication Date : 2020-08-31

Article Type : Research Paper

Abstract :St. Johns wort insert ignore into journalissuearticles values(Hypericum perforatum); is a medicinal plant that exhibits important biological activities exhibit important biological activities being antioxidant, anti-inflammatory, immunomodulatory and/or antitumour. The aim of this study was to investigate antiproliferative effect of H. perforatum oil purchased from a commercial vendor on mouse myeloma cells. The cells were treated with various concentration insert ignore into journalissuearticles values(10%, 5%, 2%, 1%, 0.5%, 0.25%, 0.2% and 0.1%); of dimethyl sulfoxide insert ignore into journalissuearticles values(DMSO); to determine the non-toxic concentration. The cells were treated with various concentrations insert ignore into journalissuearticles values(15.6-500 ppm); of the oil dissolved in DMSO to examine its antiproliferative activity. Non-toxic dose of DMSO was at the concentration of lower than 0.2%. No effect on the cell proliferation was observed in the applied concentration of the oil. In conclusion, the oil had no antiproliferative effect on Myeloma cells at these concentrations.
Keywords : Antiproliferative activity, Hypericum perforatum, Myeloma cells