Antipruritic armamentarium with short term nutritional support solution involving slymarin and curcumin for atopic dermatitis in dogs

Authors : Kerem URAL, Mehmet GÜLTEKİN, Songül ERDOĞAN, Hasan ERDOĞAN

Pages : 8-13

Doi:10.24880/maeuvfd.762776

View : 21 | Download : 15

Publication Date : 2021-04-30

Article Type : Research Paper

Abstract :Well-known medicinal plants Curcuma longa insert ignore into journalissuearticles values(turmeric); and Slybium marianum insert ignore into journalissuearticles values(slymarin); have growing interest for its therapeutic anti-inflammatory and antipruritic actions. The present researcher group hypothesized that commercially available oral/topical solution involving C. Longa and Slybium marianum combination will significantly decrease the pruritus scores after short-term insert ignore into journalissuearticles values(1 week of twice-daily); oral treatment in dogs with atopic dermatitis insert ignore into journalissuearticles values(AD);. Twenty-six dogs with AD, diagnosis based on alergen specific Ig E levels, CADESI-04 scores and clinical signs involving pruritus, previously not received any treatment. Evaluations included Owner Pruritus VAS score insert ignore into journalissuearticles values(OPVAS);, Veterinarian Dermatitis VAS score insert ignore into journalissuearticles values(VDVAS); and in vitro allergy testing. The mean day 0 OPVAS were similar insert ignore into journalissuearticles values(p>0.05); between the Silifort paste treatment groups insert ignore into journalissuearticles values(STG); insert ignore into journalissuearticles values(range 2-10); and placebo control dogs insert ignore into journalissuearticles values(CG); insert ignore into journalissuearticles values(range 2-10);, respectively. The mean OPVAS continued to gradually decrease over the remaining 6 days of study in TG insert ignore into journalissuearticles values(p 0.05); between the STG insert ignore into journalissuearticles values(range 2-10); and CG insert ignore into journalissuearticles values(range 2-10);, respectively. At day 7, the mean VDVAS for STG had decreased to 1 cm and for the placebo CG to 5.2 cm insert ignore into journalissuearticles values(p<0.0001);. The VDVAS in STG were significantly lower compared to STG on day 7 insert ignore into journalissuearticles values(p<0.0001);. The present study supports a potential benefit of Silifort paste for short-term relieving itching sensation. This treatment modality might replace immunosuppressive applications, with its anti-inflammatory, anti-infectious and antioxidant formulation.
Keywords : curcumin, dog, pruritis, slymarin