Investigating the Role of IL-17A gene rs2275913 Variant in Rosacea: In Silico Analysis Suggests Further Studies

Authors : Ali Çağatay Can Coşkun, Suzan Demir Pektaş, Çilem Özdemir, Ayşegül Demirtaş Bilgiç, Murat Cenik, Tuba Edgünlü

Pages : 139-144

Doi:10.47572/muskutd.1469931

View : 27 | Download : 8

Publication Date : 2024-12-18

Article Type : Research Paper

Abstract :Interleukine-17 (IL-17), a crucial component of the body\\\'s immune response against pathogens, is also implicated in various inflammatory processes. Notably, the skin of rosacea patients exhibits chronic inflammation, and IL-17 is known to induce the production of additional pro-inflammatory chemokines and cytokines. This inflammatory cascade can contribute to the hallmark features of rosacea, including dilated blood vessels, immune cell infiltration, and the development of papules and pustules. The study aimed to examine whether a specific genetic variation in the IL-17A gene (-197 G>A; rs2275913) is associated with rosacea susceptibility. We compared the IL-17A variant and rosacea risk in 31 healthy individuals and 25 with rosacea. Genotyping of the IL-17A variant was performed using the PCR-RFLP method. Genotype and allele frequency distributions were compared across groups using the chi-square test (χ2). Additionally, gene ontology (GO) analysis of the IL-17A gene using web-based tools is also demonstrated. No significant association between the rs2275913 polymorphism and rosacea susceptibility was observed in this study (p=0.124) but in silico analysis suggested that the IL-17A gene interaction network might play a role in the disease. Given its critical function in regulating IL-17A and related genes, particularly in immune defense and inflammatory processes, further investigation into its potential influence on rosacea development is required.
Keywords : IL-17A, İnflamatuar Sitokinler, Gen Polimorfizmi, Rosacea

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