An Investigation of TRIM36 Expression in Breast Cancer

Authors : Aycan Çelik, Sevim Karakaş Çelik, Güldeniz Karadeniz Çakmak, Fürüzan Köktürk

Pages : 21-26

Doi:10.47572/muskutd.1600240

View : 43 | Download : 26

Publication Date : 2025-04-30

Article Type : Research Paper

Abstract :Breast cancer is the most frequently diagnosed cancer type worldwide and ranks 2nd among cancers that cause death. While the role of TRIM36 has been investigated in certain human cancers, such as prostate and lung cancer, its functions remain largely unexplored. In this study, the expression level of TRIM36, whose role in breast cancer has not been previously examined, and its potential association with breast cancer pathogenesis were analyzed. RNA was isolated from normal and tumor tissues of 45 breast cancer patients. Complementary DNA (cDNA) was synthesized from the RNA, and mRNA expression levels of GAPDH and TRIM36 were quantified using qRT-PCR. TRIM36 expression was observed in breast tissues; however, no statistically significant difference was found in TRIM36 mRNA expression levels, normalized to GAPDH, between normal and tumor tissues (p=0.731). Although this study suggests that TRIM36 gene expression levels in breast cancer tissues do not differ from normal tissues, the limited sample size highlights the need for more comprehensive studies to elucidate the relationship between the TRIM36 gene and breast cancer.
Keywords : Gen Ekspresyonu, Meme Kanseri, TRIM36

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