Investigation of the Physiological and Histopathological Effects of Omega Acids (3, 6, 9) and Stearic Acid on Rats in Ischemia Reperfusion

Authors : Tuğba Karahan, Okan Arıhan, Gokhan Oto, Serkan Yildirim, Ahmet Ufuk Kömüroğlu, Fatih Karahan

Pages : 12-23

Doi:10.18586/msufbd.1371063

View : 47 | Download : 51

Publication Date : 2024-07-01

Article Type : Research Paper

Abstract :Ischemia causes reversible or irreversible cell or tissue damage due to insufficient blood flow to the organ or tissue. In this study, our aim is to investigate the protective effect of omega 3, 6 9 and stearic acid application before ischemia reperfusion injury in the leg muscles. For this purpose, 70 female albino rats were divided into 10 groups. The study continued at the same dose for 14 days. In addition, these fatty acids were given to other groups without ischemia-reperfusion. After the application different faty acid, blood biochemical parameters of different fatty acids, oxidative stress parameters and histopathology of tissues (liver, kidney, muscle) were examined in rats. As a result, it was observed that omega 9 fatty acid has better protective properties compared to other omega fatty acids and stearic acid in terms of histopathological properties and oxidative stress index. Additionally, other fatty acids and stearic acid provided some degree of protection against the deleterious effects of ischemia-reperfusion
Keywords : İskemi reperfüzyon, toplam antioksidan durumu, toplam oksidan durumu, omega yağ asitleri, stearik asit, oksidatif stres