- Aksaray Üniversitesi Tıp Bilimleri Dergisi
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- Impact of Various ANA Results and ANCA Serotypes on the Outcome of Patients with ANCA-Associated Vas...
Impact of Various ANA Results and ANCA Serotypes on the Outcome of Patients with ANCA-Associated Vasculitis
Authors : Emrah Salman
Pages : 23-29
View : 40 | Download : 107
Publication Date : 2026-01-19
Article Type : Research Paper
Abstract :Aim: We aimed to demostrate how antinuclear antibody (ANA) and ANCA serotypes affect ANCA-associated vasculitis (AAV) patients\\\' results. Material method: This retrospective cohort analysis analyzed 10,726 Turkish tertiary hospital serum samples over 4.5 years. ANCA indirect immunofluorescence test (IIF) and ANCA Enzyme-Linked Immunosorbent Assay (ELISA) testing were requested by all patients. Results: Among 10,726 patients, there were 920 patients with positive ANCA IIF and/or ANCA ELISA test. Of the 920 patients, 18 of the 98 patients with AAV were concomitant connective tissue patients, so 80 AAV patients were included in the study. Organ involvement in these very rare patients was pulmonary (63.75%), ear-nose-throat (43.75%), renal (38.75%), joint (38.75%), skin (20%), neurological (20%), ocular (17.5%), gastrointestinal (11.25%), and cardiac (2.5%) systems. Proteinuria (51.25%), renal biopsy (48.75%), hematuria (37.5%), hypertension (56.25%), chronic renal failure (36.25%), diabetes (21.25%), coronary artery disease (10%), and asthma (8.75%) were present. ANA was found in 42.5% of 80 patients. Renal involvement and coronary artery disease were more common in ANA-positive patients (p =.0,14 and p=0.50). ANA-negative patients had higher ear, nose, and throat involvement (p=.026). PR3–ANCA individuals had higher ocular involvement (p =.020). In MPO-ANCA individuals, asthma was more common (p=.002). Conclusion: AAV patients with ANA had more renal impairment than those without. Renal biopsy is recommended to distinguish AAV from systemic lupus erythematosus. Eye morbidity is greater in PR3-ANCA. The effects of ANA and ANCA serotypes in AAV patients need more study.Keywords : Antinükleer antikor, Antinötrofil sitoplazmik antikor, vaskülit, organ tutulumu.
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