Akut Lenfoblastik Lösemili Çocuklarda İdame Tedavisinin Nadir Bir Komplikasyonu: Folik Asit Eksikliği

Authors : Mustafa BÜYÜKAVCI, Olena ERKUN, Ayşegül PALA, Mehmet Fatih ORHAN

Pages : 701-704

Doi:10.26453/otjhs.742731

View : 21 | Download : 14

Publication Date : 2020-12-30

Article Type : Other Papers

Abstract :Vitamin B12 insert ignore into journalissuearticles values(cobalamin); and folic acid play a crucial role in DNA synthesis, cell division and proliferation. Their deficiency may cause serious disorders of hematopoietic, gastrointestinal and neurologic system. A 14-year-old girl, undergoing maintenance chemotherapy insert ignore into journalissuearticles values(methotrexate, 6-mercaptopurine); for acute lymphoblastic leukemia insert ignore into journalissuearticles values(ALL);, presented with the complaints of pallor and nose bleeding. At admission, white blood cells insert ignore into journalissuearticles values(WBC); was 2230/mm3, hemoglobin 6.2 gr/dL, mean corpuscular volume insert ignore into journalissuearticles values(MCV); 122 fL and thrombocytes 26700/mm3. Peripheral blood smear revealed hypersegmented neutrophils, macrocytosis, anisocytosis, rare normoblasts and 4-5 platelet per field. Bone marrow aspiration and biopsy did not confirm the pre-diagnoses of relapsed ALL, hemophagocytic lymphohistiocytosis insert ignore into journalissuearticles values(HLH); and myelodysplastic syndrome insert ignore into journalissuearticles values(MDS);. Vitamin B12 and folic acid were prescribed after obtaining the results of vitamin B12 insert ignore into journalissuearticles values(587 pg/mL);, folic acid insert ignore into journalissuearticles values(1.3 ng/mL); and homocystein insert ignore into journalissuearticles values(21 µmol/L);. Folic acid deficiency must be kept in mind in childrenwith ALL receiving maintenance therapy. Serum cobalamin and folic acid levels must be checked in case of unexplained pancytopenia.
Keywords : Anemi, Folik asit, lösemi, Pansitopeni