AN IN VITRO ASSESSMENT OF THE BIOACTIVE, CYTOTOXIC, AND ANTIDIABETIC POTENTIAL OF DIFFERENT PARTS OF TUMBLEWEED (GUNDELIA TOURNEFORTII L.)

Authors : Gözde Kutlu, Kubra Feyza Erol

Pages : 28-41

Doi:10.15237/gida.GD24096

View : 115 | Download : 105

Publication Date : 2025-02-15

Article Type : Research Paper

Abstract :This study aimed to investigate the physicochemical properties, bioactive compounds, cytotoxicity, and antidiabetic potential of the tumbleweed plant’s roots (TR), stems & leaves (TSL), and flowers (TF). Results indicated TF as the richest part in bioactive compounds and antioxidant capacity, with the highest crude protein (13.91%), crude oil (15.50%), total phenolic content (214.64 mg GAE/g), total monomeric anthocyanin content (1132.96 mg/g), ABTS (25.48 mg TE/g), CUPRAC (203.92 mg TE/g), and FRAP (32.63 µmol Fe²⁺E/g) activities. Mineral contents varied, with Mg, K, and Ca present in significant amounts across all parts. TF also showed the highest α-glucosidase (61.99%) and α-amylase (54.92%) inhibition, suggesting strong antidiabetic potential. Cytotoxicity was weak across samples, with IC50 values ranging from 1049.76 to 1641.08 μg/ mL against HEK-293 and Caco-2 cells. These findings highlight TF as the most bioactive and nutritionally rich part of the tumbleweed plant.
Keywords : Gundelia tournefortii L. bitkisi, biyoaktif özellikler, antidiyabetik potansiyel, antiproliferatif özellikler, mineral içeriği.

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