WALDENSTRÖM MAKROGLOBULİNEMİLİ HASTALARIMIZIN KLİNİK ÖZELLİKLERİ VE PROGNOZ: TEK MERKEZ DENEYİMİ / CLINICAL CHARACTERISTICS AND PROGNOSIS OF PATIENTS WITH WALDENSTRÖM`S MACROGLOBULINEMIA: SINGLE CENTER EXPERIENCE

Authors : Hava Teke, Eren Gündüz, Neslihan Andıç, Cengiz Bal, Beyhan Aras, Olga Akay
Pages : 9-13
Doi:10.20515/otd.41180
View : 36 | Download : 7
Publication Date : 2015-12-25
Article Type : Other Papers
Abstract :Özet:  Waldenström Makroglobulinemisi insert ignore into journalissuearticles values(WM); immunglobulin insert ignore into journalissuearticles values(Ig);M protein artışı ile karakterize lenfoplazmasitik bir lenfomadır. Anemi, trombositopeni, hepatosplenomegali insert ignore into journalissuearticles values(HSM);, lenfadenopati insert ignore into journalissuearticles values(LAP); ve nadiren de hipervizkosite hastalığın klinik özelliklerindendir. Yaş, hemoglobin düzeyi, trombosit sayısı, beta-2 mikroglobulin ve monoklonal IgM miktarı prognoz üzerine etkili faktörlerdendir. Hastalarımızın %84’ünde HM, %47’inde SM ve %63’ünde LAP saptandı. En sık başvuru semptomu %47,4 ile halsizlik, yorgunluktu. Hastalarımızın yaklaşık yarısı yüksek risk skoruna sahip olup ortalama yaşam süreleri 67 ay idi. ANAHTAR KELİMELER: Waldenström makroglobulinemisi, prognoz.   CLINICAL CHARACTERISTICS AND PROGNOSIS OF PATIENTS WITH WALDENSTRÖM`S MACROGLOBULINEMIA: SINGLE CENTER EXPERIENCE Abstract:  Waldenström’s Macroglobulinemia insert ignore into journalissuearticles values(WM); is a lymphoplasmacytic lymphoma associated with a monoclonal immunoglobulin insert ignore into journalissuearticles values(Ig);M protein. The clinical manifestations of the disorder are anemia, thrombocytopenia, hepato-splenomegaly insert ignore into journalissuearticles values(HSM);, lymphadenopathy insert ignore into journalissuearticles values(LAP);, and rarely hyperviscosity. Age, hemoglobin level, platelet count, beta-2 microglobulin, and monoclonal IgM concentrations are characteristics required for prognosis. The clinical manifestations in our patients were hepatomegaly 84%, splenomegaly 47%, and lymphadenopathy 63%. The most common presenting symptom was fatigue. Our patients’ risk scores were high and their overall survival was 67 months. KEY WORDS: Waldenström ‘s Macroglobulinemia, prognosis
Keywords : ANAHTAR KELİMELER Waldenström makroglobulinemisi, prognoz

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