Concomitant Endometrioid Endometrial Carcinoma and Adult-Type Granulosa Cell Tumor in an Elderly Patient with Mismatch Repair Deficiency: A Case Report

Authors : Müge Ateş Tıkız, Elif Iltar, Fatma Ceren Güner, Selen Dogan

Pages : 137-140

Doi:10.20515/otd.1698081

View : 25 | Download : 69

Publication Date : 2025-12-15

Article Type : Other Papers

Abstract :We present the case of an 82-year-old woman who was admitted with postmenopausal bleeding and was subsequently diagnosed with synchronous endometrioid endometrial carcinoma (FIGO grade 2) and adult-type granulosa cell tumor of the ovary. Histopathological and immunohistochemical analyses revealed mismatch repair (MMR) deficiency with loss of MLH1 and PMS2 expression. The coexistence of these two tumor types in a single patient, particularly in the context of MMR deficiency, is extremely rare. The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.
Keywords : Endometriyal karsinom, Granüloza hücreli tümör, MMR yetmezliği, Lynch sendromu, Senkron tümörler, Postmenopozal kanama

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