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  • Issue:2
  • The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate tr...

The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment

Authors : Yılmaz KIROĞLU, Mine CİNBİŞ, Mevlüt BİCAN, Aziz POLAT
Pages : 109-112
View : 52 | Download : 8
Publication Date : 2008-07-01
Article Type : Research Paper
Abstract :Metotreksat, akut lenfoblastik lösemi, lenfoma veya osteosarkom gibi neoplastik hastalıklarıntedavisinde kullanılan antimetabolit grubu bir kemoterapötik ajandır. Metotreksatın myelosüpresyon,mukozit, hepatik ve tubüler nekroz ile santral sinir sistemi toksisitesi gibi değişik yan etkileribulunmaktadır. Bu makalede akut lenfoblastik lösemi tanısı alan iki olguda metotreksat kullanımısonucu gelişen santral sinir sistemi nörotoksisitesinin klinik ve radyolojik bulguları ile uzun dönemizlemleri sunulmuştur.
Keywords : Metotreksat, akut lenfoblastik lösemi, nörotoksisite, manyetik rezonans görüntüleme

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