- Sinop Üniversitesi Fen Bilimleri Dergisi
- Cilt: 10 Sayı: 1
- Investigation of Antioxidant/Oxidant Potential of Some Natural Biomaterials
Investigation of Antioxidant/Oxidant Potential of Some Natural Biomaterials
Authors : Aysel Güven, Haci Ahmet Deveci, Tülay Allahverdi, Ertugrul Allahverdi, Meriç Yavuz Çolak
Pages : 234-243
Doi:10.33484/sinopfbd.1554557
View : 36 | Download : 34
Publication Date : 2025-06-29
Article Type : Research Paper
Abstract :Recent studies have focused on plant-based antioxidative materials and biomaterials that serve as remedies or preventive agents against oxidative stress-induced damage in organisms. Various methods exist to evaluate the antioxidant potential of these compounds. Antioxidants neutralize free radicals in biological cells, mitigating their harmful effects on living organisms. This study aimed to investigate the $in$ $vivo$ protective effects of naringin, silymarin and ellagic acid which are known to contribute to tissue repair following short-term ischemia/reperfusion (I/R) injury. Three-week-old, clinically healthy, Wistar albino rats (n: 35), weighing 250-300 g, were used in this study. Blood samples were analyzed for plasma paraoxonase (PON), total sialic acid (TSA), total antioxidant capacity (TAC) and total oxidant capacity (TOC), oxidative stress index (OSI) and nitric oxide (NO) levels. Results demonstrated that TSA, TOC and NO levels decreased while TAC and PON levels increased following biomaterial administration ($P$<0.05). This study confirmed that silymarin, naringin and ellagic acid exhibit free radical scavenging, anti-inflammatory, radioprotective, antiulcerogenic, and analgesic properties. Given the obtained $in$ $vivo$ results, we conclude that, they might be considered as promising candidates to reduce the effects and the levels of oxidative stress during $in$ $vivo$ and $in$ $vitro$ applicationsKeywords : Serbest radikal, iskemi/reperfüzyon, nitrik oksit, toplam antioksidan/oksidan kapasite
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