ASSOCIATION BETWEEN MCT1 GENE POLYMORPHISM (rs1049434) WITH THE ATHLETIC PERFORMANCE OF ELITE TRACK AND FIELD ATHLETES

Authors : Celal BULĞAY, Erdal ZORBA, Işık BAYRAKTAR, Hasan Huseyin KAZAN, Korkut ULUCAN, Mehmet Ali ERGUN

Pages : 127-134

Doi:10.33689/spormetre.1198404

View : 55 | Download : 12

Publication Date : 2023-03-31

Article Type : Research Paper

Abstract :Monocarboxylate transporter 1 insert ignore into journalissuearticles values(MCT1; SLC16A1); is a proton-dependent cotransporter/exchanger, located on the apical membrane of cells. MCT1 is able to transport several monocarboxylates including lactate, pyruvate and acetate, which makes this protein critical in terms of the athletic performances. The rs1049434 polymorphism in the MCT1gene was frequently associated with the performance of the athletes in different populations. The present study aims to decipher any possible association of the rs1049434 polymorphism with the personal best of elite track and field athletes. A total of sixty elite athletes insert ignore into journalissuearticles values(31 sprint/power and 29 endurance); and twenty control/sedentary with the ages of 18-35 voluntarily participated in the study. The International Association of Athletics Federations insert ignore into journalissuearticles values(IAAF); score scale was used to determine the performance levels of the personal best insert ignore into journalissuearticles values(PB); of the athletes. Whole exome sequencing insert ignore into journalissuearticles values(WES); was performed by the genomic DNA isolated from blood of the participants. Sport type, sex and PB were chosen as the parameters to compare within and between the groups by logistic regression models. The sex was not the criterion that was significantly different between or within the groups. Although PB scores were not significant within the sprint/power group, it was significant within the endurance group by the codominant insert ignore into journalissuearticles values(p=0.044);, dominant insert ignore into journalissuearticles values(p=0.016); and over-dominant insert ignore into journalissuearticles values(p=0.048); models. The rs1049434 polymorphism in the MCT1 gene may be linked to the PB of the endurance athletes. However, other genetic alterations should be regarded to conclude the effect of this polymorphism. The multi-factorial genetic background that could associate with the athletic performance is still under investigation in our research group. Nevertheless, further studies with more participants are needed.
Keywords : Atletizm, sporcu, koşucu, rs1049434, polimorfizm, MCT1, SLC16A1

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