CCL11 rs16969415 and CCR3 rs4987053 gene variants and endometrial cancer risk

Authors : Emine Yağcı, Muhammed Olgen, Gamze Zengin, Cansu Özbayer, Tufan Öge, Hülyam Kurt

Pages : 162-169

Doi:10.21673/anadoluklin.1598648

View : 86 | Download : 80

Publication Date : 2025-05-29

Article Type : Research Paper

Abstract :Aim: Endometrial cancer is the sixth most frequent malignancy in women worldwide. Chemokines are tiny cytokines that are produced to enable different cell types to migrate in different directions. They are crucial for a number of physiological functions, including immunological responses, wound healing, and the development of cancer. Our study aimed to determine the association between CCL11 rs16969415 and CCR3 gene rs4987053 variants and the risk of endometrial cancer. Methods: Ninety healthy controls and ninety endometrial cancer patients participated in this case-control research. Blood samples were used to obtain genomic DNA, and the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method was used to determine genotypes. Results: The CCL11 gene rs16969415 and the CCR3 gene rs4987053 genotype distributions and allele frequencies were found to differ substantially between the patient and control groups (respectively p<0.001, p<0.05). Conclusions: As a conclusion, the CCL11 rs16969415 and CCR3 rs4987053 variations were determined to be closely associated with endometrial cancer risk.
Keywords : Endometrium kanseri, kemokin, sitokinler

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