Evaluation of varicella zoster virus IgM, IgG and avidity results used in the diagnosis of varicella zoster virus

Authors : Emel Çalışkan

Pages : 185-190

Doi:10.21673/anadoluklin.1641218

View : 41 | Download : 91

Publication Date : 2025-05-29

Article Type : Research Paper

Abstract :Aim: Varicella zoster virus (VZV) is a disease that is rapidly transmitted through the respiratory tract and has a high seroprevalence worldwide. This study aimed to evaluate the results of VZV IgM, VZV IgG and VZV avidity serological tests studied in our laboratory. Methods: In this study, the VZV IgM, VZV IgG, and VZV avidity test results in serum samples sent to our laboratory for preliminary diagnosis or screening of chickenpox between November 2019 and December 2024 were retrospectively examined. Kruskal-Wallis and Chi-Square tests were used to evaluate the results according to mean age, gender, and years. Results: In this study, VZV IgG positivity was found to be 88.5% (2721/3074) and VZV IgM positivity was found to be 5.2% (51/990). VZV IgG negativity was found to be 7.8% (122/1569) in females of childbearing age, and 7% (4/57) in elderly individuals over 65 years of age. In only three of the 29 samples in which both IgG and IgM were requested and both were found positive, the avidity test was performed and found to be high avidity. No low avidity result was detected. No statistical significant difference was detected between the patients whose VZV IgM and VZV IgG results were positive, negative or borderline values according to gender and age means. In addition, no statistical significant difference was detected between the years in terms of VZV IgM and VZV IgG results. Conclusion: Despite the high positivity of VZV IgG, antibody screening with VZV IgG can be recommended for high-risk groups. In addition, it was considered appropriate to study the VZV avidity test as a reflex test in laboratories.
Keywords : Avidite, immünglobulin M, varisella-zoster virüsü

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