NEW THIOPHENE BEARING DIMETHYL-5-HYDROXY ISOPHTALATE ESTERS AND THEIR ANTIMICROBIAL ACTIVITIES

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Anadolu Üniversitesi Bilim Ve Teknoloji Dergisi A - Uygulamalı Bilimler Mühendislik
Volume:19 Issue:1
NEW THIOPHENE BEARING DIMETHYL-5-HYDROXY ISOPHTALATE ESTERS AND THEIR ANTIMICROBIAL ACTIVITIES

NEW THIOPHENE BEARING DIMETHYL-5-HYDROXY ISOPHTALATE ESTERS AND THEIR ANTIMICROBIAL ACTIVITIES

Authors : Hakan ÜNVER, Zerrin CANTURK

Pages : 43-49

Doi:10.18038/aubtda.335519

View : 42 | Download : 11

Publication Date : 2018-03-31

Article Type : Research Paper

Abstract :Thiophene belongs to a class of heterocyclic compounds. In this study, three new dimethyl-5-hydroxy isophtalate derived thiophene esters were successfully synthesized and characterized by FT-IR, elemental analysis, 1 H-NMR, 13 C-NMR and HR-Mass techniques. Synthesized compounds antimicrobial effects were tested on Staphylococcus aureus (ATCC 25923); Enterococcus faecalis (ATCC 29212); Enterococcus faecalis (ATCC 51922); Klebsiella pneumoniae (ATCC 700603); Pseudomonas aeruginosa (ATCC 27853); Escherichia coli (ATCC 35218); Escherichia coli (ATCC 25922) and Candida albicans (ATCC 90028); Candida glabrata (ATCC 90030); Candida krusei (ATCC 6258); Candida parapsilosis (ATCC 22019). Compound C 1 showed the highest antimicrobial activity, possessing the same potential as chloramphenicol against, P. aeruginosa ATCC 27853. According to MTT assays, this compound was identified as non-toxic.
Keywords : Thiophene, Antibacterial, Anticandidal, MIC, Ketokanazole

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