Hydrogels Synthesized from Natural Bacterial Polysaccharides with Therapeutic Effects on Cutaneous Wounds

Authors : Merve İlayda Doğan, Derya Önal Darılmaz

Pages : 260-270

Doi:10.46810/tdfd.1671294

View : 105 | Download : 174

Publication Date : 2025-12-30

Article Type : Review Paper

Abstract :Skin injuries, the largest organ in the human body, arise from various causes, and the processes involved in wound healing are of significant importance. The stages of wound repair occur at varying intervals, depending on the wound type. Bacterial infection is a major challenge in the wound-healing process. However, current wound dressing materials often fail to adequately address the clinical need to mitigate bacterial infections. In this context, hydrogels that protect the wound surface from microorganisms and facilitate rapid healing have attracted attention for wound treatment. Natural polymers such as polysaccharides are commonly used in hydrogel synthesis. These polymers can be derived from animal, plant, bacterial, or marine sources. The natural origin of polysaccharides imparts biodegradable and biocompatible properties to hydrogel-based wound dressings. In particular, bacterial polysaccharides offer cost-effective and easily producible alternatives to other polysaccharides, owing to their growth characteristics and ability to utilize diverse substrates. This review aimed to examine the effects of natural polysaccharide-based hydrogels on the healing of infected wounds and the advantages of hydrogel dressings synthesized from natural polysaccharides for treating skin wounds of various etiologies. It also highlights recent advancements in hydrogels synthesized using bacterial polysaccharides among natural polymers. This review posits that the use of bacterial polysaccharides in the synthesis of hydrogel dressings for various wound treatments provides a novel perspective.
Keywords : Hidrojel, Doğal polimerler, Bakteriyel polisakkaritler, Yara tedavisi

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