Comparison of Anticancer Capacity of Six Grape Extracts on Cancerous Liver Cell Line

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Türk Doğa ve Fen Dergisi
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Comparison of Anticancer Capacity of Six Grape Extracts on Cancerous Liver Cell Line

Comparison of Anticancer Capacity of Six Grape Extracts on Cancerous Liver Cell Line

Authors : Laila Elfogohi, Oktay Bıyıklıoğlu, Aslı Uğurlu Bayarslan, Serhat Karabıcak, İdris Yazgan, Talip Çeter

Pages : 85-89

Doi:10.46810/tdfd.1712868

View : 76 | Download : 120

Publication Date : 2025-12-30

Article Type : Research Paper

Abstract :Grape is one of the most widely consumed food sources worldwide and has been under massive research for its health benefits. In this study, we used ethanolic extracts from six different grape cultivars (both white and black grapes) to test their anticancer capacity for Huh7 liver cancer cell line. The findings showed that the grape cultivar species play the role on the cytotoxicity, which was observed as biphasic dose dependent. Based on the findings and the literature, it can be claimed rather than using whole grape extracts, fractionation of the extracts is needed to isolate bioactive compounds due to the fact that flavonoids can serve as cytotoxicity and cytoprotective behaviors depending on their chemistry.
Keywords : Grape extract, Huh7 cell line, Cancer, Cytotoxicity, Flavonoids

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