Ocular toxicity assessment of Bisphenol A and its derivatives by The Hen`s Egg Test

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Ocular toxicity assessment of Bisphenol A and its derivatives by The Hen`s Egg Test - Chorioallantoi...

Ocular toxicity assessment of Bisphenol A and its derivatives by The Hen`s Egg Test - Chorioallantoic Membrane (HET-CAM) assay

Pages : 254-259

View : 53 | Download : 129

Publication Date : 2025-12-30

Article Type : Research Paper

Abstract :Bisphenol A (BPA) and its derivatives, Bisphenol F (BPF), Bisphenol S (BPS) are classified as endocrine disruptor chemicals that can affect with the human in different ways. In raising concerns about the adverse health effects of these chemicals, no ocular irritation data is available in the literature. It was aimed to reveal the comparative irritation potential of BPA and its analogues for the first time with HET-CAM test, which is an alternative method to the in vivo Draize test. Irritancy or alterations of BPA, BPF and BPS were detected by observing adverse changes such as hemorrhage, coagulation, or lysis of blood vessels on the CAM surface. Test results indicate that BPA caused moderate irritation characterized by lysis with an invisible vein, whereas BPS had a strong irritation impact appearing as hemorrhage and coagulation. There was no irritancy after BPF exposure on the CAM surface. As a conclusion, it was supported that BPA and BPS serious toxic chemicals for human health when considering exposure that may be higher for workers. At the same time, this study is significant since it offers an alternative approach to animal studies for evaluating the irritation potential of bisphenols, particularly in the context of industrial exposures.
Keywords : Bisphenol, toksisite, irritasyon, in vitro, HET-CAM

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