Are obese rats influenced by GLP1 and IR through aerobic exercise? A case study

Authors : Ali SAYYAH, Hamid MOHEBBI, Hamid ARAZI, Abbas BAHARI

Pages : 1-7

View : 38 | Download : 13

Publication Date : 2016-08-31

Article Type : Research Paper

Abstract :The present study aimed to consider the influence of aerobic exercise intensity on GLP-1and IR in obese rats. Glucagon-like peptide-1 insert ignore into journalissuearticles values(GLP-1); is characterized as incretion hormones secreted from the intestine upon ingestion of food to maximize insulin secretion, regulate blood sugar and enhance insulin resistance insert ignore into journalissuearticles values(IR);. It was an in vitro study. The study subjects were thirty-two male Wistar rats which were divided into 4 groups: three levels of aerobic training intensity insert ignore into journalissuearticles values(high, moderate and low intensity); and one control group. Following 8 weeks of different intensity of aerobic trainings, the researchers calculated plasma concentration of glucose, insulin, HOMA-IR and GLP-1. We applied dependent t-test and Analysis of variance insert ignore into journalissuearticles values(ANOVA); to test the research hypotheses. Body weight, BMI, insulin, blood glucose and HOMA-IR in high, moderate and low intensity of aerobic training were noticed to be significantly lower than in the control group insert ignore into journalissuearticles values(P=0.001); following  an eight-week intervention. However, moderate and high intensity of aerobic training compared with low intensity significantly showed a decrease in insulin, blood glucose, HOMA-IR, and GLP-1. The findings revealed that moderate and high intensity of aerobic training results in GLP-1 secretion impairment, thus its improvement can cause a reduction in insulin resistance and blood glucose regulation.
Keywords : Aerobic exercise, glucagon like peptide 1, swimming exercise

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