Effect of Boldenone Administration on Some Organ Damage Markers in Trained Rats

Authors : Batuhan Karaduman, Sefa Lök

Pages : 364-370

Doi:10.15314/tsed.1504981

View : 93 | Download : 102

Publication Date : 2024-12-31

Article Type : Research Paper

Abstract :The aim of this study was to examine the effects of Boldenone administration on skeletal muscle, liver and heart organs in exercised rats. Rats were divided into 4 groups as Control(C), Exercise (E), Boldenone(B) and Boldenone + Exercise (BE). There are 6 rats in the C and E groups and 7 rats in the other groups. The rats in groups E and BE were given a 45-minute treadmill exercise 5 days a week at a speed of 1.5km/hour for 8 weeks. In the statistical evaluation of the data, the results were given as mean±SD using the SPSS 22 package program. ANOVA and Duncan tests were used to compare the data between groups. At the end of the 8-week study, blood samples taken from rats were found to be significantly higher in AST and CK-MB values in B and BE groups than in C and E groups as a result of the statistical analysis (p0,05), it was observed that the mean values of the B and BE groups were higher than the mean values of the C and E groups in both parameters. LDH values were significantly higher in E, B and BE groups compared to C group (p<0.05). With the result obtained from the findings; It has been observed that the use of AAS increases liver enzyme levels (ALT, AST, ALP, LDH) and CK-MB levels, which is a marker of heart muscle damage. With these findings, it can be said that the use of Anabolic Androgenic Steroids has negative effects on the heart and liver. In addition, the fact that the mean values of the BE group were higher than the other groups in all parameters, as exercise did not reduce the amount of these negative side effects of AASs, indicates that exercise may increase these side effects even more.
Keywords : Anabolik androjenik steroidler, Boldenon, Egzersiz, İskelet kası, Kalp

ORIGINAL ARTICLE URL