Frequency of Low Immunglobuline level in Pre-School Recurrent Wheezing

Authors : Merve Yoldaş Çelik, Ilknur Külhaş Çelik, Tayfur Giniş, Betül Büyüktiryaki, Muge Toyran, Emine Dibek Misirlioğlu, Can Naci Kocabaş, Ersoy Civelek

Pages : 439-444

Doi:10.12956/tchd.1268678

View : 141 | Download : 126

Publication Date : 2023-11-27

Article Type : Research Paper

Abstract :Objective: Immunoglobulin lowering may be associated with recurrent wheezing symptoms and clinic by increasing the tendency to viral respiratory tract infections. This study aimed to investigate the frequency of immunoglobulinemia in preschoolers with wheezing. Material and Methods: The study was conducted between 01.01.2013 - 01.01.2016 between T.C. University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training, and Research Hospital, The Pediatric Allergy and Immunology Clinic included patients who had been followed up and treated for at least one year with recurrent wheezing attacks within 72 months. The patients’ immunoglobulin (G, A, M) values were retrospectively analyzed. Immunoglobulin levels were determined to be normal and low according to age limits. Results: The study included 585 patients (65.6% male, 34.4% female) under the age of 6 years with a mean age of 26.9 months. The mean follow-up period of the patients is 2.2 years. In 33.7% of these patients, at least one immunoglobulin was low. None of these patients had any signs or symptoms of immunodeficiency. Immunoglobulin A was low in 21% of the patients, immünglobulin G in 18%, and immünglobulin M in 7.5% of all patients. Conclusion: Hypogammaglobulinemia was found in approximately 1/3 of the patients. There were no signs of immunodeficiency in these patients. Whether this is a special group in preschooler recurrent wheezing and hypogammaglobulinemia combination should be etiologically investigated.
Keywords : okul öncesi tekrarlayan vizing, düşük immunglobulin, immunglobulin G, immunglobulin M, immunglobulin A

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