Comprehensive Evaluation of Sibling Cases with Type 1 Diabetes

Authors : İrem Turgay Yağmur, Şervan Özalkak, Nurdan Yıldırım, Zehra Aycan, Şenay Savaş Erdeve, Semra Çetinkaya
Pages : 373-380
Doi:10.12956/tchd.1519873
View : 64 | Download : 37
Publication Date : 2024-11-18
Article Type : Research Paper
Abstract :Objective: Type 1 diabetes mellitus (T1DM) is a polygenic disease influenced by genetic, environmental, immunological factors.There are few studies regarding siblings with T1DM.We aimed to evaluate the presentation, diagnosis, follow-up, sociodemographic characteristics of sibling T1DM cases. Material and Methods: We retrospectively reviewed characteristics of sibling cases followed with T1DM between January 2005 and May 2017. Results: The prevalence of T1DM sibling diabetes in our clinic was 5.9%.We included 17 siblings (a total of 34 cases) who had diagnosis and follow-up data. One of the siblings was a twin.There were no statistically significant differences between the ages at diagnosis, presenting symptoms, duration of symptoms before diagnosis, glucose/C-peptide values at diagnosis, average HbA1c values in the first five years of follow-up, or hospitalization rates in the first five-years post-diagnosis between the first and second diagnosed siblings.Despite having a child diagnosed with T1DM, 23.6% of families had a second child diagnosed with diabetic ketoacidosis.Variations in antibody positivity were observed among siblings, there were no similarities between celiac disease, Hashimoto’s thyroiditis.Vitamin D levels were significantly lower in siblings diagnosed secondarily. Conclusion: Our study is significant for being conducted at a reference center with a high number of diabetes patients under follow-up, for filling a gap in the literature with a detailed evaluation of sibling cases with T1DM.It serves as a comprehensive pilot study examining the manner, order of diagnosis, clinical, laboratory, and follow-up data of siblings with diabetes.There is a need for prospective studies with a larger number of sibling cases to further explore this topic.
Keywords : Tip 1 diyabetes mellitus, diyabetli kardeş, D vitamini

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