Histopathological and Antioxidant Effects of Bromelain on Kidney Tissue of Tyloxapol-Induced Hyperlipidemic Rats

Authors : Ayşe Nurseli Sulumer, Esra Palabıyık, Bahri Avcı, Handan Uğuz, Hakan Aşkın

Pages : 413-422

Doi:10.53433/yyufbed.1381717

View : 76 | Download : 53

Publication Date : 2024-08-31

Article Type : Research Paper

Abstract :This study was designed to investigate the nephroprotective effect of Bromelain against oxidative stress induced by Tyloxopol-induced hyperlipidemia in rats. Rats (n=6) were divided into three groups. I: Control (C) Group: No treatment was given and only distilled water was given; II: Tyloxapol (TX) Group: Group receiving Tyloxapol (400 mg/kg, i.p); III: Tyloxapol + Bromelain (TX+BR) Group: Group receiving Tyloxapol (400 mg/kg, i.p.) and group receiving Bromelain (250 mg/kg, o.d.) for 18 days. As a result of Tyloxapol administration, oxidative stress parameters SOD and CAT levels decreased, while MDA levels increased. In addition, histopathologic variations were detected in kidney sections. On the other hand, lipid peroxidation decreased and most of the studied parameters improved with combined administration (TX+BR group). According to the results obtained, bromelain may be a potent and alternative agent with protective effect for further studies.
Keywords : Böbrek, Bromelain, Hiperlipidemi, Histopatoloji, Oksidatif stres, Tyloxapol

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