Relationship Between Effective Sevoflurane Consumption and Metabolic Age- A Prospective Observational Study

Authors : Tuğçe Gazioğlu Kişi, Duygu Demiröz Aslan, Oya Olcay Yılmaz, Bahar Uslu Bayhan
Pages : 137-149
Doi:10.33716/bmedj.1699032
View : 55 | Download : 175
Publication Date : 2025-12-30
Article Type : Research Paper
Abstract :Abstract Background: Sevoflurane is usually administered according to the minimum alveolar concentration. Age is an important variable affecting the minimum alveolar concentration and it should be kept in mind that two individuals of the same chronologic age may have different metabolic ages. The purpose of this study is to evaluate the relationship between metabolic age, chronological age and sevoflurane consumption in patients with sufficient depth of anesthesia. Methods: Bioelectrical impedance analysis of 79 patients aged 18-65 years, chronological age, metabolic age and other metabolic parameters were recorded. To standardize the relationship between sevoflurane consumption and chronological age and metabolic age, patients were divided into three groups using the percentage age difference formula; Group A; age difference 11.7%. Results: The study included 79 patients, 29.1% of whom were women. The mean chronologic and metabolic ages of the patients were 31.29 ± 11.9 and 30.42 ± 12.89 years, respectively. A significant difference was seen between chronologic and metabolic age and total sevoflurane consumption (p=0.006; p=0.007) and a weak negative correlation was observed (r= -0.304; r=-0.301). When the sevoflurane consumption amounts of the groups were compared, a notable difference was observed among the three groups (p<0.001). Sevoflurane consumption was higher in patients whose metabolic age was younger than chronologic age compared to other groups. Conclusion: Metabolic age was associated with sevoflurane consumption, and sevoflurane consumption decreased in patients with chronologic age older than metabolic age.
Keywords : Sevofluran, Sevofluran Tüketim Miktarı, Metabolik Yaş, Kronolojik Yaş, Vücut Kompozisyon Analizi, Tanita, Bazal Metabolizma Hızı

ORIGINAL ARTICLE URL