Female Gender and Older Age Are a Predictor Of Coronary Artery Tortuosity In Patients With No Coronary Artery Disease

Onur Argan; Buğra Nalinci; Yavuz Selim Akgün; Tarık Yıldırım; Özgen Şafak; Mehmet Tolga Hekim; Seda Elçim Yıldırım; Didar Elif Akgün; Eyüp Avcı; Halil Lütfi Kısacık

doi:10.33716/bmedj.1828954

Female Gender and Older Age Are a Predictor Of Coronary Artery Tortuosity In Patients With No Coronary Artery Disease

Authors : Onur Argan, Buğra Nalinci, Yavuz Selim Akgün, Tarık Yıldırım, Özgen Şafak, Mehmet Tolga Hekim, Seda Elçim Yıldırım, Didar Elif Akgün, Eyüp Avcı, Halil Lütfi Kısacık

Pages : 169-177

Doi:10.33716/bmedj.1828954

View : 71 | Download : 152

Publication Date : 2025-12-30

Article Type : Research Paper

Abstract :Objective: Coronary artery tortuosity (CAT) is frequently observed in invasive angiography, though its aetiology and clinical significance remain ambiguous. The aim of our study was to investigate the parameters affecting CAT in patients without normal coronary artery disease (CAD). Materials and Methods: 110 patients with CAT and no CAD and and 140 patients with no CAT and CAD were evaluated retrospectively. CAT was defined by ≥3 bends with a change in vessel direction of ≥45° present in both systole and diastole along the main trunk of at the least one coronary artery. Demographic, biochemical, echocardiogrphic and angiographic parameters were compared between groups. Results: Patients with CAT were older and more often female gender. 24 (21.8%) were males and 86 (78.2%) were females in patients with CAT. The mean age of the patients with CAT were 61.4±10.6 years and the control group was 55.9±10.9 years. Among the patients with CAT, 62.7% had hypertension, 27.3% had diabetes mellitus and 30% were smokers. But, there was not significant difference between groups (p=0.469, p=0.446, p=0.242, respectively) . Left anterior descending artery (LAD) was the most commonly affected tortuous coronary artery (86.4%). Multivariate analysis showed significant relationship between age (p=0.019), female gender (p<0.001) and CAT. Conclusion: We found that female gender and older age were a major predictor of CAT in patients with no CAD. Other traditional risk factors such as diabetes mellitus, hypertension and smoking were thought not to influence the development of CAT. LAD was the most commonly affected tortuous coronary artery. Further researches are required to understand the mechanisms underlying sex and age related changes in the arterial wall related with CAT.
Keywords : Koroner arter tortuozitesi, Yaşlanma, Cinsiyet

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