Determination of hepatoprotective and antioxidant role of thyme (origanum onites L.) infusion against ethyl alcohol induced oxidative stress in rats

Authors : Shreen MUSA, İsmail ÇELİK

Pages : 54-61

Doi:10.17678/beuscitech.749849

View : 39 | Download : 6

Publication Date : 2020-12-28

Article Type : Research Paper

Abstract :In this study, we aimed to determine the hepatoprotective and antioxidants role of thyme insert ignore into journalissuearticles values(O. onites); against ethyl alcohol insert ignore into journalissuearticles values(EtOH); induced oxidative stress in rats. The experiment conducted as control, 20% EtOH, 3% O. onites infusion and 3% O. onites + 20% EtOH groups. The antioxidant and hepatoprotective role of O. onites infusion was evaluated by histopathological chance and serum damage biomarkers of liver insert ignore into journalissuearticles values(LDB);, antioxidant constituents insert ignore into journalissuearticles values(ACs); and malondialdehyde insert ignore into journalissuearticles values(MDA);. According to results, Liver damage serum enzymes activities were significantly higher in 20% EtOH group compared to normal control insert ignore into journalissuearticles values(NC); whereas the parameters were significantly lower in the infusion supplemented groups compared to 20% EtOH group. Also, MDA content of 20% EtOH group increased significantly in all tissues compared to NC group but decreased as coparion with 20% EtOH. The results suggest that the infusion restored the most of the parameters towards the NC with fluctuations in the ACs.
Keywords : Origanum onites, Antioxidant, Hepatoprotective

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