Evaluation of Interleukin 6 Levels in Severe COVID-19 Patients

Authors : Yıldız OKUTURLAR, İftihar KÖKSAL, Yasemin GÜNDOĞDU, Arzu YÜKSEL, Özgür OKUTURLAR, Fadıl HAVAS, Cem GUN

Pages : 20-25

Doi:10.56016/dahudermj.1220959

View : 29 | Download : 8

Publication Date : 2023-01-29

Article Type : Research Paper

Abstract :Objectives: Interleukin 6 insert ignore into journalissuearticles values(IL-6); plays a leading role in the proliferation and differentiation of immune cells. Level of IL-6 is manifestly increased under many inflammatory conditions, including cytokine release syndrome. We evaluated the IL-6 levels of patients who were hospitalized with the diagnosis of COVID-19. Methods: In the study, the test results of 19 cases whose IL-6 levels were measured between March 11, 2020 and May 31, 2020 retrospectively. The inpatients in the covid service insert ignore into journalissuearticles values(Group 1); and the patients admitted to the Intensive Care Unit insert ignore into journalissuearticles values(ICU); of our hospital insert ignore into journalissuearticles values(Group 2); were compared and evaluated. In addition, patients with positive and negative RT-PCR test results were checked for IL-6. Results: While 8 insert ignore into journalissuearticles values(Group 1); of 19 patients observed in the clinic were transferred to the ICU, 11 patients insert ignore into journalissuearticles values(Group 2); were observed in the covid service until their discharge. Group 1 IL-6 levels insert ignore into journalissuearticles values(median 34 pg/mL); and Group 2 IL-6 levels insert ignore into journalissuearticles values(median 116 pg/mL); were found to be high in both groups insert ignore into journalissuearticles values(p = 0,099);. However, it was found to be significantly higher in patients with positive COVID-19 RT-PCR test insert ignore into journalissuearticles values(median 90.60 pg/mL); than in negative patients insert ignore into journalissuearticles values(median 29.90 pg/mL); insert ignore into journalissuearticles values(p = 0.018);. Conclusion: No significant difference in IL-6 levels between the patients who were monitored in the clinic and transferred to the ICU was found in this study. The significant difference between IL-6 levels among COVID-19 RT-PCR positive and negative patients reveals the importance of IL-6 level with regard to tocilizumab treatment in COVID-19 patients in cytokine storm. Keywords: COVID-19, Interleukin 6, Cytokine Storm, Macrophage Activation Syndrome
Keywords : COVID 19, Interleukin 6, Cytokine Storm, Macrophage Activation Syndrome

ORIGINAL ARTICLE URL