Bradykinin-Mediated Angioedema Associated with ACE Inhibitor, Managed with C1 Esterase Inhibitor

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Eurasian Journal of Critical Care
Cilt: 7 Sayı: 3
Bradykinin-Mediated Angioedema Associated with ACE Inhibitor, Managed with C1 Esterase Inhibitor

Bradykinin-Mediated Angioedema Associated with ACE Inhibitor, Managed with C1 Esterase Inhibitor

Authors : Emel Çetinkaya, Oya Güven, Tugce Uskur

Pages : 51-53

Doi:10.55994/ejcc.1772152

View : 94 | Download : 198

Publication Date : 2025-12-31

Article Type : Other Papers

Abstract :Introduction: Bradykinin-mediated angioedema is a rare clinical condition that can present diagnostic challenges, particularly when it occurs independently of C1 esterase inhibitor activity. One of the most common triggers is angiotensin-converting enzyme (ACE) inhibitors, which can lead to edema by preventing the breakdown of bradykinin. Case Presentation: A 70-year-old male patient, using an ACE inhibitor for hypertension, presented to the emergency department with tongue swelling after receiving cisplatin-docetaxel-5 fluorouracil treatment for laryngeal cancer. His symptoms did not improve with anti-allergic treatment, but showed rapid resolution following administration of C1 esterase inhibitor. Discussion: This case presents a bradykinin-mediated angioedema episode associated with ACE inhibitor use, which responded to C1 esterase inhibitor treatment. Clinicians should consider C1 esterase inhibitor therapy in cases unresponsive to standard allergy treatments.
Keywords : Bradikinin, ACE inhibitörü, Anjiyoödem, C1 esteraz inhibitörü

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