Paraoxonase Activity In Patients With Chronic Obstructive Pulmonary Disease

Authors : Kerim YEŞİLDAĞ, Turgut TEKE, Sami ERDEM

Pages : 64-68

View : 54 | Download : 9

Publication Date : 2021-08-31

Article Type : Research Paper

Abstract :Aim: We aimed to study the Paraoxonase 1 insert ignore into journalissuearticles values(PON1); activity in chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD); patients with stable condition, had acute attack and developed respiratory failure. Material and Method: Twenty-five patients with stable COPD insert ignore into journalissuearticles values(group1); insert ignore into journalissuearticles values(mean age 62.9±9.4);, 25 cases with acute COPD attack insert ignore into journalissuearticles values(group2); insert ignore into journalissuearticles values(mean age 63.8±9.0);, 25 patients with hypercapnic respiratory failure insert ignore into journalissuearticles values(group3); insert ignore into journalissuearticles values(mean age 65.0±12.9); and 25 healthy individuals for control group insert ignore into journalissuearticles values(mean age 34.8±9.8);, totally 100 cases, were enrolled to the study. Cases with secondary lipid disorder, cardiovascular disease, diabetes mellitus, renal failure, malignancy, hepatic failure and patients who receive antilipidemic or antioxidant medicines were not included to the study. All cases enrolled to the study underwent routine biochemical analysis including PON1 activity and lipid profile. Results: There was significant difference between groups with respect to PON1 levels insert ignore into journalissuearticles values(p<0.0001);. PON1 activities of COPD patient groups insert ignore into journalissuearticles values(group 1=96.8±57.4U/L; group 2=51.4±32.8U/L; group 3=47.1±27.5U/L); were lower than control group insert ignore into journalissuearticles values(185.4±110.1U/L); insert ignore into journalissuearticles values(p<0.0001);. Also, PON1 activity of stable COPD patients was higher than the COPD cases admitted with acute attack or respiratory failure insert ignore into journalissuearticles values(group2 and 3); insert ignore into journalissuearticles values(p<0.05);. Conclusion: These findings show that PON1 activity may have a role in COPD pathogenesis and endogen antioxidants might be depleted by increased oxidative stress in COPD. This also advocates that oxidative stress may have a role in acute COPD attacks.
Keywords : COPD, oxidative stress, Paraoxonase

ORIGINAL ARTICLE URL