RELATIONSHIP BETWEEN VITAMIN D LEVEL AS AN INDEPENDENT RISK FACTOR AND ONE-YEAR MORTALITY IN PATIENTS WITH HOSPITAL-ACQUIRED PNEUMONIA FOLLOWED UP IN INTENSIVE CARE UNIT

Authors : Derya HOŞGÜN, Semih AYDEMİR

Pages : 82-86

View : 43 | Download : 13

Publication Date : 2021-12-28

Article Type : Research Paper

Abstract :Background: Hospital-acquired pneumonia insert ignore into journalissuearticles values(HAP); is an important cause of mortality and morbidity among hospital-acquired infections. Vitamin D insert ignore into journalissuearticles values(25[OH]D); plays a role as an anti-inflammatory, immunomodulatory, and antimicrobial agent in infections. There are limited studies on the long-term mortality prediction of 25insert ignore into journalissuearticles values(OH);D deficiency in HAP and the findings are controversial. In this study, our primary aim was to investigate the role of 25insert ignore into journalissuearticles values(OH);D level measured during hospital admission as an independent risk factor for one-year mortality in HAP patients requiring intensive care. Materials and Methods: The retrospective study included patients that were diagnosed with HAP and admitted to the intensive care unit insert ignore into journalissuearticles values(ICU); between 2014 and 2018. Relationship between pretreatment 25insert ignore into journalissuearticles values(OH);D level and one-year independent mortality was evaluated. Vitamin D deficiency was defined as a 25insert ignore into journalissuearticles values(OH);D level of 20 ng/ml. Results: The study included 57 patients comprising 36 insert ignore into journalissuearticles values(63.2%); men and 21 insert ignore into journalissuearticles values(36.8%); women with a mean age of 75 years. One-year independent mortality occurred in 21 insert ignore into journalissuearticles values(36.8%); patients. Mean length of ICU stay was 16 days. Mean 25insert ignore into journalissuearticles values(OH);D level was 9.53 ng/ml, which was 20 ng/ml in 10 insert ignore into journalissuearticles values(17.5%); patients. No significant relationship was found between 25insert ignore into journalissuearticles values(OH);D level and one-year independent mortality and the length of ICU stay insert ignore into journalissuearticles values(p=0.477 and p=0.941, respectively);. Similarly, no significant relationship was found between 25insert ignore into journalissuearticles values(OH);D level and APACHE II, age, length of ICU stay, and one-year independent mortality insert ignore into journalissuearticles values(p=0.621, p=0.933, p=0.410, and p=0.933, respectively);. Conclusion: We consider that multicenter, double-blind randomized controlled studies are needed to substantiate the definition of vitamin D deficiency and the optimal vitamin D level to be achieved with replacement therapy in order to evaluate the effect of the therapy on the course of the disease and long-term independent mortality in HAP patients followed up in ICU.
Keywords : HOSPİTAL ACQUIRED PNEUMONIA, MORTALITY, INTENSIVE CARE UNİT, 25 OH, D

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