Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema

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Eurasian Journal of Critical Care
Volume:6 Issue:2
Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema

Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema

Authors : Sertaç Güler, Dilber Üçöz Kocaşaban, Mehmet Ali Ata, Secdegül Coşkun Yaş, Yahya Kemal Günaydın

Pages : 83-84

Doi:10.55994/ejcc.1469585

View : 50 | Download : 41

Publication Date : 2024-09-05

Article Type : Other Papers

Abstract :Angioedema describes a non-dependent, non-pitting and transient edema caused by the accumulation of vasoactive substances in the circulation. These vasoactive substances increase vascular permeability, causing swelling of the deep dermal, submucosal or subcutaneous tissues of the face, lips, neck, extremities or gastrointestinal tract. Urticaria may or may not accompany this condition. Angioedema is generally mediated through two pathways: histamine-mediated and bradykinin-mediated. Histamine-mediated angioedema generally responds to standard therapeutic measures (such as antihistamines, steroids and epinephrine), whereas bradykinin-mediated angioedema can be more difficult to manage in emergency departments (ED). Here, we present a patient who presented to our ED with bradykinin-mediated ACE-I-associated dramatic angioedema clinic, did not respond to standard treatments, rapidly improved with fresh frozen plasma (FFP) administration and was discharged after 6 days of follow-up in the emergency critical intensive care unit.
Keywords : angioedema, fresh frozen plasma, emergency medicine

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