Relationship Between Atherogenic Indices and Cardiovascular Thromboembolic Events in Patients with COVID-19 Pneumonia

Authors : Hakan Kilci, Adem Melekoğlu, Güneş Melike Doğan, Mutlu Cagan Sumerkan, Özgür Selim Ser, Ertuğrul Altınbilek

Pages : 227-234

Doi:10.52827/hititmedj.1594744

View : 38 | Download : 38

Publication Date : 2025-06-23

Article Type : Research Paper

Abstract :Objective: COVID-19, caused by coronavirus SARS-CoV-2, is a pandemic viral respiratory infection in which venous and arterial thromboembolic events are often observed. This study aimed to investigate the relationship between atherogenic indices and cardiovascular thromboembolic events in patients with COVID-19 pneumonia. Material and Method: In this retrospective study, a total of 805 inpatients (median age 63 [IQR: 52-74] years; 45.1% female) who were diagnosed with COVID-19 pneumonia between March 2020 and December 2020 were evaluated. Patients were divided into two groups based on cardiovascular thromboembolic events with cardiovascular thromboembolic events (n=96) and without-cardiovascular thromboembolic events (n=709). All clinical and demographic data and laboratory results were analyzed. Atherogenic Index of Plasma (AIP (log10 (triglyceride/ HDL)), Atherogenic Coefficient (AC (HDL/ non-HDL)), Risk Index of Castelli-I (CRI-I (Total cholesterol/ HDL)), and Risk Index of Castelli-II (CRI-II (LDL/ HDL)) were calculated. Results: Atherogenic Coefficient, CRI-I, and CRI-II values were significantly higher in the cardiovascular thromboembolic event group (p=0.001, p=0.001, p=0.007, respectively). AIP values were higher in the cardiovascular thromboembolic events group but were not statistically significant (p=0.051). In the cardiovascular thromboembolic events group, HDL values were found to be significantly lower (p=0.001), but CRP and D-dimer values were found to be significantly higher (p<0.001, p=0.006, respectively). In the multivariable analysis, Atherogenic Coefficient (OR: 1.294, 95% CI: 1.089-1.1537, p=0.003), D-dimer, Hypertension, and current smoking were found to be independent predictors of cardiovascular thromboembolic events in patients with COVID-19 pneumonia. Conclusion: Atherogenic indices could be used to predict cardiovascular thromboembolic events in patients with COVID-19 pneumonia.
Keywords : Aterojenik indeksler, COVID-19 pnömonisi, kardiyovasküler olaylar

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