The role of perivascular adipose tissue on human saphenous vein vascular tone

Authors : Gülsev ÖZEN, B Sönmez UYDEŞ DOĞAN, Önder TESKİN, Xavier NOREL, Gökçe TOPAL

Pages : 1-13

View : 44 | Download : 11

Publication Date : 2016-08-24

Article Type : Research Paper

Abstract :Perivascular adipose tissue insert ignore into journalissuearticles values(PVAT); is situated outside of almost every blood vessel. Recent studies showed that PVAT provides mechanical support for blood vessels and secretes vasoactive adipokines that could regulate vascular tone. However, most of the studies evaluating PVAT effects on vascular tone have been performed with vessels derived from animals. Therefore, we aimed to investigate the role of PVAT surrounding human coronary bypass graft vessels such as saphenous vein insert ignore into journalissuearticles values(SV);. Human SV preparations were set up in an organ bath in the presence or absence of their PVAT. The presence of PVAT significantly attenuated the contractile response to prostaglandin F2α insert ignore into journalissuearticles values(PGF2α);. However, potassium chloride insert ignore into journalissuearticles values(KCI);-induced concentration-response curve wasn’t modified in PVAT-intact SV preparations. On the other hand, endothelium-dependent relaxation induced by acetylcholine insert ignore into journalissuearticles values(ACh); or endothelium-independent relaxation induced by sodium nitroprusside insert ignore into journalissuearticles values(SNP); were similar between SV with PVAT versus SV without PVAT preparations. Sensitivity of the SV to contractile agonists insert ignore into journalissuearticles values(KCI, PGF2α); or relaxant agonists insert ignore into journalissuearticles values(SNP, ACh); were not modified in the presence of PVAT. These results suggest that PVAT could decrease PGF2α-induced contractile tone via endothelium-independent mechanisms in SV. Retaining PVAT in SV preparations during bypass graft surgery could prevent graft vasospasm possibly via PVAT derived relaxant factorinsert ignore into journalissuearticles values(s);.
Keywords : Perivascular adipose tissue, human saphenous vein, vascular tone

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