In vitro skin permeation of escin in the new gel formulation of Aesculus hippocastanum (Horse Chestnut)

Authors : Esra EROĞLU ÖZKAN, Burcu MESUT, Abdulselam POLAT, Nur TAN

Pages : 79-88

View : 40 | Download : 15

Publication Date : 2016-12-26

Article Type : Research Paper

Abstract :Aesculus hippocastanum L. insert ignore into journalissuearticles values(Hippocastanaceae); is used in topical  pharmaceutical and cosmetic formulations by industries. The aim of this work  is to develop a new A. hippocastanum product having good stability and better  skin permeation compared with the other products on the market. Two new gel  formulations were prepared to evaluate escin ex vivo permeation through pig skin  by using Franz-type diffusion and to analyse by HPLC. The first gel formulation  has contained only A. hippocastanum extract insert ignore into journalissuearticles values(G1); and the second gel formulation  has contained a mixture of A. hippocastanum and M. chamomilla extracts insert ignore into journalissuearticles values(G2);,  as active ingredients. The reference gel has escin as active ingredient and it was  purchased from a pharmacy. G2 showed significantly better skin permeation ability  with good stability compared to G1 and reference gel. Owing to its favourable  penetration and stability characteristics the new gel formulation could be an  alternative for the treatment of chronic venous insufficiency and inflammatory  soft tissue inflammation.
Keywords : Aesculus hippocastanum, gel, escin, HPLC, stability

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