Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis

Authors : Muhammad Zakariyyah AUMEERUDDY, Zaahira AUMEERUDDYELALFİ, Hudaa NEETOO, Gökhan ZENGİN, Bianca FİBRİCH, Sunelle RADEMAN, Analike Blom Van STADEN, Karina SZUMAN, İsa Anina LAMBRECHTS, Namrita LALL, Mohamad Fawzi MAHOMOODALLY

Pages : 89-99

View : 59 | Download : 9

Publication Date : 2018-12-01

Article Type : Research Paper

Abstract :This study was designed to evaluate and correlate the biological, phytochemical, and physicochemical properties of two NSS insert ignore into journalissuearticles values(Nigella sativa seed); oils insert ignore into journalissuearticles values(N1 and N2);. The biological activity was evaluated in terms of antibacterial, antioxidant insert ignore into journalissuearticles values(nitric oxide scavenging);, antielastase, antityrosinase, antimelanogenic, and anticancer activity. Physicochemical properties including colour, total soluble solids insert ignore into journalissuearticles values(TSS);, and density were also investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular antimelanogenic, and anticancer activity against the HeLa cell line compared to N1, which showed higher antityrosinase activity. TPC insert ignore into journalissuearticles values(total phenolic content); and TFC insert ignore into journalissuearticles values(total flavonoid content); of N1 were significantly higher than N2 while TTC insert ignore into journalissuearticles values(total tannin content); was higher in N2. In fact, TTC was strongly correlated insert ignore into journalissuearticles values(R=1.000); with the antioxidant, extracellular antimelanogenic, and HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a complementary and alternative therapy in the management of infectious and chronic diseases but warrants further in vivo pharmacological validation and toxicological analysis.
Keywords : Nigella sativa, biological, phytochemical, physicochemical

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